Why Medical (and Dermatologic) Practice Has Become So Convoluted: The Complexity/Convolutional/Obfuscatory Kleptocracies.

Consider dermatology (or medical) practice from the aspect of those who manage, and seek to glean a profit from, medical management corporations, including but not limited to third party payers. Although much of the complexity burden thrust upon doctors’ offices is borne by the offices and doctors, there is also much that is borne by the companies, and the entire process appears to make no sense whatsoever. How can the business professionals who run these outfits make such blunders? Let us approach this question by examining another industry: fast food franchising

Measured noise reductions resulting from modified approach procedures for business jet aircraft

Five business jet airplanes were flown to determine the noise reductions that result from the use of modified approach procedures. The airplanes tested were a Gulfstream 2, JetStar, Hawker Siddeley 125-400, Sabreliner-60 and LearJet-24. Noise measurements were made 3, 5, and 7 nautical miles from the touchdown point. In addition to a standard 3 deg glide slope approach, a 4 deg glide slope approach, a 3 deg glide slope approach in a low-drag configuration, and a two-segment approach were flown. It was found that the 4 deg approach was about 4 EPNdB quieter than the standard 3 deg approach. Noise reductions for the low-drag 3 deg approach varied widely among the airplanes tested, with an average of 8.5 EPNdB on a fleet-weighted basis. The two-segment approach resulted in noise reductions of 7 to 8 EPNdB at 3 and 5 nautical miles from touchdown, but only 3 EPNdB at 7 nautical miles from touchdown when the airplanes were still in level flight prior to glide slope intercept. Pilot ratings showed progressively increasing workload for the 4 deg, low-drag 3 deg, and two-segment approaches

Ready, Set, Communicate: Measuring Usability of Instructional Modules Designed to Improve Communications Skills of Students Studying Agricultural Sciences

Well-developed communications skills are essential to a proficient agricultural workforce. Online instruction via reusable learning modules (RLMs) is one way agricultural science faculty can provide their students with expert communications skills training. Although RLMs have many benefits, their value degrades rapidly if the learner cannot access or use the technology efficiently. Therefore, online instruction must be tested to ensure usability. The purpose of our study was to assess the usability of RLMs developed to bolster the communications skills of students studying in the agricultural sciences and provide guidance for future curricula and online instruction development. We used quantitative and qualitative data sources to assess the usability of three RLMs, according to N = 21 students. The usability metrics we assessed included learnability, navigation, video function, document access and readability, quiz and assignment practicality, and task difficulty. The RLMs garnered high usability scores from participants who had positive impressions and experiences completing them. Participants demonstrated an increase in confidence to perform communications skills and an increase in knowledge about communications after completing the modules. They thought embedded videos, documents, quizzes, and assignments were helpful in learning communications concepts. Some recommended improving navigation, document readability, and assignment details. Based on our findings, we recommend RLM developers embed short videos, printable handouts, and quizzes into RLMs, and include an overview of documents’ key points to guide reading. Participants’ positive feedback and willingness to engage with the RLMs suggests incorporating the RLMs into agricultural science courses will help students develop into science communicators

Lead Bullet Fragments in Venison from Rifle-Killed Deer: Potential for Human Dietary Exposure

Human consumers of wildlife killed with lead ammunition may be exposed to health risks associated with lead ingestion. This hypothesis is based on published studies showing elevated blood lead concentrations in subsistence hunter populations, retention of ammunition residues in the tissues of hunter-killed animals, and systemic, cognitive, and behavioral disorders associated with human lead body burdens once considered safe. Our objective was to determine the incidence and bioavailability of lead bullet fragments in hunter-killed venison, a widely-eaten food among hunters and their families. We radiographed 30 eviscerated carcasses of White-tailed Deer (Odocoileus virginianus) shot by hunters with standard lead-core, copper-jacketed bullets under normal hunting conditions. All carcasses showed metal fragments (geometric mean = 136 fragments, range = 15–409) and widespread fragment dispersion. We took each carcass to a separate meat processor and fluoroscopically scanned the resulting meat packages; fluoroscopy revealed metal fragments in the ground meat packages of 24 (80%) of the 30 deer; 32% of 234 ground meat packages contained at least one fragment. Fragments were identified as lead by ICP in 93% of 27 samples. Isotope ratios of lead in meat matched the ratios of bullets, and differed from background lead in bone. We fed fragment-containing venison to four pigs to test bioavailability; four controls received venison without fragments from the same deer. Mean blood lead concentrations in pigs peaked at 2.29 µg/dL (maximum 3.8 µg/dL) 2 days following ingestion of fragment-containing venison, significantly higher than the 0.63 µg/dL averaged by controls. We conclude that people risk exposure to bioavailable lead from bullet fragments when they eat venison from deer killed with standard lead-based rifle bullets and processed under normal procedures. At risk in the U.S. are some ten million hunters, their families, and low-income beneficiaries of venison donations

STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle.

Human papillomaviruses (HPV) activate a number of host factors to control their differentiation-dependent life cycles. The transcription factor signal transducer and activator of transcription (STAT)-3 is important for cell cycle progression and cell survival in response to cytokines and growth factors. STAT3 requires phosphorylation on Ser727, in addition to phosphorylation on Tyr705 to be transcriptionally active. In this study, we show that STAT3 is essential for the HPV life cycle in undifferentiated and differentiated keratinocytes. Primary human keratinocytes containing high-risk HPV18 genomes display enhanced STAT3 phosphorylation compared to normal keratinocytes. Expression of the E6 oncoprotein is sufficient to induce the dual phosphorylation of STAT3 at Ser727 and Tyr705 by a mechanism requiring Janus kinases and members of the MAPK family. E6-mediated activation of STAT3 induces the transcription of STAT3 responsive genes including cyclin D1 and Bcl-xL. Silencing of STAT3 protein expression by siRNA or inhibition of STAT3 activation by small molecule inhibitors, or by expression of dominant negative STAT3 phosphorylation site mutants, results in blockade of cell cycle progression. Loss of active STAT3 impairs HPV gene expression and prevents episome maintenance in undifferentiated keratinocytes and upon differentiation, lack of active STAT3 abolishes virus genome amplification and late gene expression. Organotypic raft cultures of HPV18 containing keratinocytes expressing a phosphorylation site STAT3 mutant display a profound reduction in suprabasal hyperplasia, which correlates with a loss of cyclin B1 expression and increased differentiation. Finally, increased STAT3 expression and phosphorylation is observed in HPV positive cervical disease biopsies compared to control samples, highlighting a role for STAT3 activation in cervical carcinogenesis. In summary, our data provides evidence of a critical role for STAT3 in the HPV18 life cycle

Theory of ultracold Fermi gases

The physics of quantum degenerate Fermi gases in uniform as well as in harmonically trapped configurations is reviewed from a theoretical perspective. Emphasis is given to the effect of interactions which play a crucial role, bringing the gas into a superfluid phase at low temperature. In these dilute systems interactions are characterized by a single parameter, the s-wave scattering length, whose value can be tuned using an external magnetic field near a Feshbach resonance. The BCS limit of ordinary Fermi superfluidity, the Bose-Einstein condensation (BEC) of dimers and the unitary limit of large scattering length are important regimes exhibited by interacting Fermi gases. In particular the BEC and the unitary regimes are characterized by a high value of the superfluid critical temperature, of the order of the Fermi temperature. Different physical properties are discussed, including the density profiles and the energy of the ground-state configurations, the momentum distribution, the fraction of condensed pairs, collective oscillations and pair breaking effects, the expansion of the gas, the main thermodynamic properties, the behavior in the presence of optical lattices and the signatures of superfluidity, such as the existence of quantized vortices, the quenching of the moment of inertia and the consequences of spin polarization. Various theoretical approaches are considered, ranging from the mean-field description of the BCS-BEC crossover to non-perturbative methods based on quantum Monte Carlo techniques. A major goal of the review is to compare the theoretical predictions with the available experimental results.Comment: Revised and abridged version accepted for publication in Rev. Mod. Phys.: 63 pages, 36 figure

A Unified Description of Cuprate and Iron Arsenide Superconductors

We propose a unified description of cuprate and iron-based superconductivity. Consistency with magnetic structure inferred from neutron scattering implies significant constraints on the symmetry of the pairing gap for the iron-based superconductors. We find that this unification requires the orbital pairing formfactors for the iron arsenides to differ fundamentally from those for cuprates at the microscopic level.Comment: 12 pages, 10 figures, 2 table

Ultra-cold Polarized Fermi Gases

Recent experiments with ultra-cold atoms have demonstrated the possibility of realizing experimentally fermionic superfluids with imbalanced spin populations. We discuss how these developments have shed a new light on a half- century old open problem in condensed matter physics, and raised new interrogations of their own.Comment: 27 pages; 8 figures; Published in Report in Rep. Prog. Phys. 73 112401 (2010